The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review
Nutrients 2023, 15(11), 2477; https://doi.org/10.3390/nu15112477
Laila Salameh 1,2,*,Walid Mahmood 1,Rifat Hamoudi 2,3ORCID,Khulood Almazrouei 4,Mahesh Lochanan 2,Suheyl Seyhoglu 2ORCID and Bassam Mahboub 2
1 Dubai Academic Health Corporation, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates
2 Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates
3 Division of Surgery and Interventional Science, University College London, London HA4 4LP, UK
4 Zayed Military Hospital, Abu Dhabi P.O. Box 72763, United Arab Emirates
Asthma is a common chronic respiratory disease that affects millions of people worldwide, and its prevalence continues to increase. Vitamin D has been proposed as a potential environmental factor in asthma pathogenesis, due to its immunomodulatory effects. This systematic review aimed to evaluate the effect of vitamin D supplementation in order to prevent airway remodeling in asthmatic patients. Four electronic databases, namely PubMed, Embase, Clinical trails.gov, and CINAHL, were thoroughly searched to conduct a comprehensive literature review. The International Prospective Register of Systematic Reviews (CRD42023413798) contains a record of the registered protocol. We identified 9447 studies during the initial search; 9 studies (0.1%) met the inclusion criteria and were included in the systematic review.
All included studies were experimental studies that investigated the impact of vitamin D supplementation on airway remodeling in asthma.
The studies included in this review suggest that vitamin D
- inhibits airway smooth muscle cell contraction and remodeling,
- reduces inflammation,
- regulates collagen synthesis in the airways, and
- modulates the action of bronchial fibroblasts.
However, one study suggests that TGF-β1 can impair vitamin D-induced and constitutive airway epithelial host defense mechanisms. Overall, vitamin D appears to have a potential role in the prevention and management of asthma.
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