Cognition improved in 5 ways after Vitamin D increased to 32 ng (50,000 weekly) – June 2023

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The effect of vitamin D on neurocognitive functions in older vitamin D deficient adults: a pilot longitudinal interventional study

Psychogeriatrics. 2023 Jun 30. doi: 10.1111/psyg.12997 $12 rents PDF from publisher
Banu Ozulu Turkmen 1, Busra Can 2, Seda Buker 3, Birsu Beser 3, Deniz Büyükgök 3, Bahar Dernek 4, Sevilay Bovatekin 1, Pınar Kucukdagli 1, Birkan Ilhan 1, Şükriye Akça Kalem 3, Nilgun Erten 1, Mehmet Akif Karan 1, Gulistan Bahat 1

Background: The relationship between vitamin D and cognitive status remains controversial. We aimed to evaluate the effect of vitamin D replacement on cognitive functions in healthy and cognitively intact vitamin D deficient older females.

50,000 IU weekly of Vitamin D for 2 months, then test at 6 months

Methods: This study was designed as a prospective interventional study. A total of 30 female adults aged ≥60 with a serum 25 (OH) vitamin D level of <10 ng/ml were included. Participants were administered 50 000 IU vitamin D3 weekly for 8 weeks followed by a maintenance therapy of 1000 U/day. Detailed neuropsychological assessment was performed prior to vitamin D replacement and repeated at 6 months by the same psychologist.

Results: Mean age was 63 ± 6.7 years and baseline vitamin D level was 7.8 ± 2.0 (range: 3.5-10.3) ng/ml. At 6 months, vitamin D level was 32.5 ± 3.4 (32.2-55) ng/ml. The

1. Judgement of Line Orientation Test (P = 0.04),
2. inaccurate word memorizing of the Verbal Memory Processes Test (P = 0.02),
3. perseveration scores of the Verbal Memory Processes Test (P = 0.005),
4. topographical accuracy of the Warrington Recognition Memory Test (P = 0.002), and the
5. spontaneous self-correction of an error in the Boston Naming Test (P = 0.003)

scores increased significantly, while the

• delayed recall score in the Verbal Memory Processes Test (P = 0.03),
• incorrect naming of words in the Boston Naming Test (P = 0.04),
• interference time of the Stroop Test (P = 0.05), and
• spontaneous corrections of the Stroop Test (P = 0.02)

scores decreased significantly from baseline.

Conclusion: Vitamin D replacement has a positive effect on cognitive domains related to visuospatial, executive, and memory processing functions.

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Vitamin D Life – Cognitive category contains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

373 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
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Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search Vitamin D Life for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014