- Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes - Sept 2019
- Vitamin D response cut in half in diabetics with poor CYP2R1 or GC genes - RCT Aug 2025
- Poor Genes => less Vitamin D
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13 Items in Diabetes and Genetics 5 Items in Diabetes and D Binding protein Vitamin D level and gene polymorphisms in Korean children with type 1 diabetes - Sept 2019
Pediatr Diabetes. 2019 Sep;20(6):750-758. doi: 10.1111/pedi.12878
Nam HK1, Rhie YJ2, Lee KH3.BACKGROUND:
Vitamin D metabolism has been associated with type 1 diabetes.OBJECTIVE:
We aimed to clarify the association of 25-hydroxylase (CYP2R1) and 1α-hydroxylase (CYP27B1) with risk of developing type 1 diabetes in Korean children.METHODS:
In total, 252 children (96 type 1 diabetes and 156 healthy controls) under the age of 20 years were recruited. Serum 25-hydroxyvitamin D (25OHD) and 1α,25-dihydroxyvitamin D [1α,25(OH)2 D] levels were determined. Allelic, genotypic, and haplotypic distribution of CYP2R1 (rs12794714, rs10766196, rs10741657, rs2060793, and rs10766197) and CYP27B1 (rs4646536, rs10877012, and rs3782130) polymorphisms were determined. Clinical and biochemical data were analyzed according to genotype.RESULTS:
Mean vitamin D level was considerably lower, and vitamin D deficiency was more prevalent in children with type 1 diabetes than in healthy controls. The GG genotype of CYP2R1 rs12794714 and AA genotype of CYP2R1 rs10766196 were significantly associated with risk of developing type 1 diabetes (odds ratio 2.00, 95% confidence interval 1.176-3.413 and odds ratio 1.88, 95% confidence interval 1.103-3.195, respectively). The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes. These genotypes did not differ with respect to glycosylated hemoglobin and daily insulin requirement.CONCLUSIONS:
Serum 25OHD and 1α,25(OH)2 D levels were lower in children with type 1 diabetes than in healthy controls. CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes. Thus, polymorphisms in vitamin D metabolism may contribute to susceptibility to type 1 diabetes in Korean children.Vitamin D response cut in half in diabetics with poor CYP2R1 or GC genes - RCT Aug 2025
Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D3 supplementation in prediabetes
Randomized Controlled Trial Eur J Clin Nutr 2025 Aug;79(8):770-773. doi: 10.1038/s41430-024-01564-z
Peng Ni # 1, Ze Xu # 2, Yujing Zhang # 2, Dongdong Zhang 2, Hongwei Wen 3, Yaping Liu 2, Wenjie Li 4, Xing Li 5Background: Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D3 supplementation responsiveness in prediabetes.
Methods: A total of 240 prediabetic participants received orally 1600 IU of vitamin D3 or placebo daily for 24 weeks.
Results: CYP2R1 rs12794714 AA carriers had less increased 25(OH)D3 levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D3 levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).
Conclusions: The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D3 supplementation responsiveness in prediabetes.
Poor Genes => less Vitamin D
- CYP2R1 gene reduces response to Vitamin D - many studies
- Genes (CYP2R1 and GC) which restrict the amount of Vitamin D which gets into bloodstream – June 2014
- Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
- Increased risk of diabetes if have poor Vitamin D genes – Dec 2020
- Genetics
Note; Most reductions of Vitamin D getting to cells are not noticed by Vitamin D tests - Vitamin D Binding Protein 180+ studies
- There is a >2X increase in 11+ health problems if have poor VDBP (GC)
- Glutathione improves Vitamin D in 9 ways
- Liposomal Glutathione improves; CYP2R1, CYP27A1, CYP27B1, VDBP, VDR and CYP24A1
13 Items in Diabetes and Genetics - DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D) – Feb 2024
- Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022
- Increased risk of diabetes if have poor Vitamin D genes – Dec 2020
- Diabetes and poor Vitamin D genes - many studies
- Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetes changes liver genes so as to destroy (catabolize) Vitamin D – May 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation – Jan 2014
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Fructose reduces blood levels of active vitamin D
- Type 1 diabetes, genes and vitamin D
- Vitamin D genes and insulin resistance – MS Aug 2010
5 Items in Diabetes and D Binding protein - T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Type 1 diabetes patients may be pissing away vitamin D – Jan 2011
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