Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis—Data from a Single-Center Analysis
J. Clin. Med. 2024, 13(5), 1296; https://doi.org/10.3390/jcm13051296
Konstantin Horas 1,*,†ORCID,Gerrit Maier 2,†,Maximilian Rudert 1ORCID,Axel Jakuscheit 1ORCID,Manuel Weißenberger 1,3ORCID,Ioannis Stratos 1ORCID,Tizian Heinz 1,Dominik Rak 1ORCID,Philip Mark Anderson 1ORCID andJörg Arnholdt 4
Background: Rapidly destructive osteoarthritis (RDO) of the hip joint is characterised by the rapid destruction of the femoral head with or without acetabular involvement. There has been increasing interest in this disease over the past years; however, the entity is still poorly understood, and its pathophysiology remains unknown. Yet, there is ample evidence today that increased bone metabolism might play a role in the onset and progression of the disease. Vitamin D is of utmost importance to maintain a balanced bone metabolism. However, whether vitamin D deficiency is involved in disease development remains to be elucidated. Further, the vitamin D status of patients with RDO has not yet been analysed. For this reason, the objective of this study was to assess the vitamin D status of patients with RDO. Moreover, the aim was to clarify whether there is a difference in the vitamin D status of patients with RDO compared with patients with primary osteoarthritis (OA).
Methods: In this single-centre analysis, the 25(OH)D, PTH, and calcium levels of 29 patients who presented with RDO between 2020 and 2022 were assessed. Results: Altogether, 97% of patients (28/29) were vitamin D deficient, a further 3% (1/29) were vitamin D insufficient, and not a single patient presented with a sufficient vitamin D status. Notably, the vitamin D levels of RDO patients (mean = 11.04 ng/mL) were significantly lower than the vitamin D levels of patients with OA (mean = 22.16 ng/mL, p = 0.001).
Conclusion: In conclusion, we found a widespread and high rate of vitamin D deficiency in patients with RDO. Hence, we believe that 25(OH)D status should routinely be analysed in these patients.
Download the PDF from Vitamin D Life
Note: Do not know if low D ===> Rapid destruction or Rapid destruction ==> low D
Would be interesting to go back and see what the D levels were months before the RDO
74+ Hip fracture or joint studies in Vitamin D Life title
This list is automatically updated
Items found: 74
| Title | | Modified |
| Hip joint destroyed in months (rare) is associated with especially low Vitamin D – Feb 2024 | | 29 Feb, 2024 |
| Hip fractures 60% more likely in people who drank a lot of milk - Greger Feb 2024 | | 14 Feb, 2024 |
| Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024 | | 25 Jan, 2024 |
| Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023 | | 26 Aug, 2023 |
| Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023 | | 11 Aug, 2023 |
| Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012 | | 23 Dec, 2022 |
| Hip fractures requiring hospitalization cut in half by Vitamin K1 (100 mcg per day) – Sept 2022 | | 17 Dec, 2022 |
| More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022 | | 01 Jun, 2022 |
| Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 | | 26 Jul, 2021 |
| Recommends vitamin D after hip fracture ( but not enough and no-bone building co-factors) – May 2021 | | 21 May, 2021 |
| Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021 | | 31 Jan, 2021 |
| A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020 | | 11 Dec, 2020 |
| Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020 | | 09 Aug, 2020 |
| Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013 | | 07 Jun, 2020 |
| 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020 | | 07 Mar, 2020 |
| Hip fractures not prevented by Vitamin D (800 IU daily or large quarterly or annual doses) – meta-analysis – Dec 2019 | | 21 Dec, 2019 |
| Hip fractures reduced 16 to 33 percent by any amount of Vitamin D and Calcium – Oct 2019 | | 05 Nov, 2019 |
| Hip fracture rate increases in winter (subtropical Australia too) – Aug 2019 | | 10 Aug, 2019 |
| Warning - High intake of Vitamin B12 and B6 found to increase risk of hip fracture by 47 percent - 2019 | | 19 May, 2019 |
| Following hip fracture 2,000 IU of vitamin D daily improved quality of life – Feb 2019 | | 23 Mar, 2019 |
| Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 | | 01 Feb, 2019 |
| Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018 | | 12 Dec, 2018 |
| Death of older hip fracture patients at least 1.6X more likely if low vitamin D – May 2018 | | 19 Nov, 2018 |
| France wants to reduce hip fractures by drinking 10 glasses of milk daily – April 2018 | | 01 Apr, 2018 |
| Hip fractures rates have been increasing since 2012 – Feb 2018 | | 12 Feb, 2018 |
| Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017 | | 20 Dec, 2017 |
| Hip fracture risk reduced 6 percent for each daily dairy serving (more if full-fat dairy) – Oct 2017 | | 28 Oct, 2017 |
| France is planning to reduce hip fractures by dairy vitamin D fortification (plan will not work) – 2017 | | 17 Oct, 2017 |
| Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016 | | 23 Aug, 2017 |
| Most Hip fracture patients had low vitamin D and protein (needed for strong bones) – May 2017 | | 18 May, 2017 |
| 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017 | | 19 Apr, 2017 |
| Vitamin D loading dose after hip fracture surgery was great – RCT Aug 2016 | | 06 Apr, 2017 |
| Following a stroke, a hip fracture is 6X more likely if low vitamin D – July 2001 | | 04 Mar, 2017 |
| Gene makes Hip Fracture 2.5X more likely unless get more vitamin D - Aug 2015 | | 12 Nov, 2016 |
| Partial (proximal) hip fracture strongly associated with low Vitamin D – Aug 2016 | | 08 Nov, 2016 |
| 24 years ago hip fractures were reduced 24 percent in a large trial using Vitamin D and Ca – Oct 2016 | | 22 Oct, 2016 |
| Kaiser working to decrease hip and other fractures – Nov 2011 | | 22 Oct, 2016 |
| Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015 | | 25 Sep, 2016 |
| Hip fracture risk increased 2.5X if problem with Vitamin D Receptor gene (GC) – March 2014 | | 25 Sep, 2016 |
| Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015 | | 26 Dec, 2015 |
| Hip fracture 3X more likely if low vitamin D – Dec 2015 | | 26 Dec, 2015 |
| 5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 | | 17 Jul, 2015 |
| 7 X more likely to get hip fracture if have highest level of vitamin A – Jan 2003 | | 31 May, 2015 |
| Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015 | | 27 May, 2015 |
| Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012 | | 16 Mar, 2015 |
| Hip fracture outcome 5X more likely to be poor if low vitamin D – Jan 2015 | | 16 Mar, 2015 |
| Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013 | | 20 Feb, 2015 |
| Hip Fracture – 5X more likely to have bad outcome if have less than 20 ng of vitamin D – Dec 2014 | | 22 Jan, 2015 |
| Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 | | 09 Nov, 2014 |
| Hip fracture – not getting enough vitamin D – 2013 | | 28 May, 2014 |
| Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010 | | 04 Dec, 2013 |
| Men with hip fracture were 1.6X more likely to have low vitamin D – Aug 2013 | | 09 Nov, 2013 |
| 5X increase in hip fracture rates in 65 years - 1998 | | 27 Aug, 2013 |
| Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT Feb 2013 | | 17 Aug, 2013 |
| 20 percent fewer male hip fractures if more Magnesium in the water – July 2013 | | 11 Jul, 2013 |
| Half as many hip fractures if take Calcium, hormones, and a tiny amount of vitamin D – July 2013 | | 26 Jun, 2013 |
| Male Hip fracture 1.65X more likely if low vitamin D – May 2013 | | 01 Jun, 2013 |
| Vitamin D needed to prevent and treat hip fracture, but only 20 percent got any – May 2013 | | 31 May, 2013 |
| Having less than 25 ng of vitamin D was associated with severe hip fracture – March 2011 | | 30 Jan, 2013 |
| Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012 | | 20 Dec, 2012 |
| Hip fracture and vitamin D – Health ABC study – May 2012 | | 28 Sep, 2012 |
| 2X to 3X higher hip fracture rate in Asia in past 30 years – Aug 2012 | | 18 Aug, 2012 |
| Cataract surgery resulted in 30 percent fewer hip fractures – July 2012 | | 02 Aug, 2012 |
| Hip fractures in India - editorial with recommendation - Sept 2010 | | 06 Jul, 2012 |
| Women with hip fractures very low on vitamins D3 and K – Mar 2011 | | 06 Jul, 2012 |
| Upper body bones fractured along with hip when extremely low on vitamin D – Sept 2010 | | 24 Jun, 2012 |
| 30 percent less chance of dying after hip fracture if take vitamin D and other drugs – 2011 | | 24 Jun, 2012 |
| 75 percent of hip fractures associated with vitamin D deficiency - Jan 2011 | | 24 Jun, 2012 |
| Vitamin D 2nd most recommended way to prevent next hip fracture – Nov 2010 | | 23 Jun, 2012 |
| Hip fractures worse if very low on vitamin D – Mar 2011 | | 23 Jun, 2012 |
| Hip fracture patients had only 16 ng of vitamin D – May 2011 | | 23 Jun, 2012 |
| Declining hip fracture rates in the United States – unknown reason – June 2010 | | 23 Jun, 2012 |
| Vitamin K1 reduced hip fracture but Vitamin K2 did not – Aug 2011 | | 23 Jun, 2012 |
| Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011 | | 19 Nov, 2011 |