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Low Vitamin D in Mongolia, supplementing would save lives (20 percent have rickets) – Oct 2019

A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation

Nutrients 2019, 11(10), 2452; https://doi.org/10.3390/nu11102452
William B. Grant 1,* and Barbara J. Boucher 2

  • 1 Director, Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USA
  • 2 The Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, 4 Newark Street, London E12AT, UK
Vitamin D Life

Dr. Grant on vitamin D and mortality in Vitamin D Life

Overview of Rickets and vitamin D contains the following

Rate of rickets is usually < 0.1% of births, unless dark skin or breastfed
Rate of rickets has greatly increased with the drop in vitamin D levels during the past 40 years
400 IU can prevent/treat most rickets Turkey gave vitamin D to EVERY child and eliminated Rickets
A low serum level of vitamin D does not indicate rickets
Sometimes rickets is also associated with a poor vitamin D receptor
Giving enough Vitamin D to the mother PREVENTS Rickets
Rate of rickets in some countries varies from 10% to 70% (typically poor health overall)
Rickets has been more than doubling in many countries
Rickets is strongly associated with severe breathing problems (weak ribs)
Bowed legs is not the primary indication of rickets (3 other indications of rickets are seen more often)
Vitamin D and Rickets consensus took 80 years

Rickets category has 119 items

Mongolia


This study concluded that TB is not treated by Vitamin D

TB is helped by Vitamin D, provided enough is given and Vitamin D receptor activation is increased

Reference #63: High-Dose Vitamin D3 during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial
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Study found that those with poor VDR were 2X more likely to have TB
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Overview Tuberculosis and Vitamin D has the following summary

There are many indications that vitamin D both PREVENTS and TREATS TB

  • As with many other diseases, Vitamin D Life expects that there will be a at least a 4X range of vitamin D due to:
    • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
  • Also expect that co-factors and Vitamin D Receptor activators will prove to be very important
  • UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
TB and vitamin D 107 items

Items in both categories TB and Vitamin D Receptor gene are listed here:


A poor VDR increases the risk of 54 health problems (such as TB)  click here for details


Items in both categories TB and Radomized Controlled Trials are listed here:


Items in both categories TB and Meta-analysis are listed here:


Vitamin D treats other health problems as well - such as:

COPD Overview

Overview Stroke and vitamin D

Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 194 items

 Download the PDF from Vitamin D Life
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   *Deaths/100,000 population ( Population = 3 million, so total deaths are 30X higher)

Serum 25-hydroxyvitamin D (25(OH)D) concentrations are low in Mongolia, averaging 22 ng/mL in summer and only 8 ng/mL in winter. Mongolians have high incidence and/or prevalence of several diseases linked to low 25(OH)D concentrations, including ischemic heart disease, malignant neoplasms, cirrhosis of the liver, ischemic stroke, lower respiratory tract infections, preterm birth complications, and diabetes mellitus. Fortifying regularly consumed foods such as flour, milk, and edible oils with vitamin D3 could raise 25(OH)D concentrations by about 10 ng/mL.
However, to achieve 25(OH)D concentrations of 30–40 ng/mL in adults, vitamin D intakes of 1000 to 4000 IU/day would be required, making personal supplement use necessary. On the basis of prospective observational studies and clinical trials of disease incidence or known mortality rates and adverse pregnancy and birth outcomes, raising mean serum 25(OH)D concentrations to 40 ng/mL would likely reduce incidence and mortality rates for those and other diseases, reduce the rate of adverse pregnancy and birth outcomes, and increase mean life expectancy by one year or more.

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