Poor sleep was 2X more likely if low Vitamin D and poor Vitamin D receptor – April 2024

The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

Sci Rep. 2024 Apr 7;14(1):8141. doi: 10.1038/s41598-024-58561-2.
Luiz Antônio Alves de Menezes-Júnior 1 2 3, Thais da Silva Sabião 4 5, Samara Silva de Moura 4 5, Aline Priscila Batista 6 7, Mariana Carvalho de Menezes 4 5 8, Júlia Cristina Cardoso Carraro 4 5 8, George Luiz Lins Machado-Coelho 4 6 7, Adriana Lúcia Meireles 4 5 8

To evaluate association of vitamin D with sleep quality in adults and the influence of VDR-gene polymorphism FokI (rs2228570;A > G). Cross-sectional population-based study in adults, conducted in Brazil. The outcome was sleep-quality, evaluated by the Pittsburgh Sleep Quality Index. Vitamin D was determined by indirect electrochemiluminescence and classified as deficiency (VDD), 25(OH)D < 20 ng/mL in a healthy population or 25(OH)D < 30 ng/mL for groups at risk for VDD. FokI polymorphism in the VDR-gene was genotyped by qPCR and classified as homozygous wild (FF or AA), heterozygous (Ff or AG), or homozygous mutant (ff or GG). Multivariate logistic analysis was used to estimate the association between vitamin D and FokI polymorphism with sleep-quality.
In a total of 1674 individuals evaluated, 53.6% had poor-sleep-quality, 31.5% had VDD, and the genotype frequency of the FokI polymorphism was 9.9% FF, 44.6% Ff, and 45.5% ff.
In multivariate analysis, individuals with VDD had 1.51 times the chance of poor-sleep-quality, and individuals with the ff genotype had 1.49 times the chance of poor-sleep-quality (OR:1.49;95%CI:1.05-2.12) when compared to individuals with the FF or Ff genotype.
In the combined analysis, individuals with VDD and ff genotype had more chance of poor-sleep-quality than individuals with sufficient vitamin D and genotype Ff or FF (OR:2.19;95%CI:1.27-3.76). Our data suggest that VDD and VDR FokI gene polymorphism are associated with poor-sleep-quality, and combining the two factors increases the chance of poor-sleep-quality compared to separate groups.
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Vitamin D Life - studies in both categories Sleep and Vitamin D Receptor

This list is automatically updated

Vitamin D Life – Sleep category contains

A few items in SLEEP category

• Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
• Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
• Sleep, Dr. Gominak and Vitamin D - several studies
• Restless Legs Syndrome dramatically reduced by vitamin D, etc
• On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
• Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
• The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
• The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
• Vitamin D for better sleep video - Dec 2021
• 5X increase in sleep problems in a decade in US Veterans
• Sleep Apnea and Vitamin D - many studies
• Melatonin and Vitamin D - many studies does much more than improve sleep

Vitamin D Life - The risk of 50+ diseases at least double with poor Vitamin D Receptor

Vitamin D Life - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of Vitamin D Life uses 10 of the 16 known VDR activators

Vitamin D Life – Vitamin D Receptor category contains

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR