After Colorectal Cancer Surgery the immune system was maintained by Vitamin D (8,000 IU daily) – RCT Jan 2023

Vitamin D3 Supplementation Promotes Regulatory T-Cells to Maintain Immune Homeostasis After Surgery for Early Stages of Colorectal Cancer

In Vivo . 2023 Jan-Feb;37(1):286-293. doi: 10.21873/invivo.13078.
Patnapa Srichomchey 1 2, Sophida Sukprasert 3, Nathapong Khulasittijinda 4, Narin Voravud 5, Chucheep Sahakitrungruang 6, Putthapoom Lumjiaktase 7

Background/aim: Vitamin D3 (VD3) affects the regulation of the immune system, including the differentiation and function of regulatory T-cells (Tregs). Tregs play an important role in maintaining immune homeostasis in patients with colorectal cancer (CRC). The effects of VD3 on Treg-associated immune function were investigated in Thai patients in the early stages of CRC.

Materials and methods: Twenty-eight patients were randomized to one of two groups: Untreated or treatment with VD3 for 3 months. Whole blood samples were collected at baseline, and at 1 and 3 months. Peripheral blood mononuclear cells were isolated and the populations of forkhead box P3-positive Treg cells was analyzed by flow cytometry. The levels of Treg-associated cytokines, interleukin 10 (IL-10) and transforming growth factor beta 1 (TGF-β1), were measured by enzyme-linked immunosorbent assays.

Results: Serum VD3 levels of the VD3-treated group were significantly increased at 1 (p=0.017) and 3 months (p<0.001) compared to the untreated control group. The mean percentage of Tregs was maintained between 1 and 3 months in the VD3-treated group. At 3 months, the untreated group had significantly lower Treg levels than the VD3-treated group (p=0.043). Serum IL-10 levels of the VD3-treated group were statistically increased at 1 month compared to the control group (p=0.032). No significant difference in serum TGF-β1 levels was observed between the two groups. However, the TGF-β1 level in the VD3-treated group at 1 month was lower than that of the control.

Conclusion: Our findings suggest that VD3 supplementation can maintain immune responses in the early stages of CRC, helping to control Treg function. Therefore, VD3 should be supplemented to maintain immune homeostasis, especially in patients with vitamin D deficiency.
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Note: Chemotherapy or radation therapy did NOT follow Cancer surgery in this study

Vitamin D Life - 8 studies in both categories Intervention and Colorectal Cancer

This list is automatically updated

Vitamin D Life – Cancer - Colon category contains

• Cancer - Colon category listing has 141 items

• see also:
  Overview Cancer-Colon and vitamin D.   Overview Cancer and vitamin D  Overview Gut and vitamin D   Cancer and Vitamin D - many studies
• Cancer - After diagnosis category listing has 110 items along with related searches
• 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
• Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
• Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021

Vitamin D Life – Cancer - After diagnosis category contains

• Most cancers reduce vitamin D levels
• Most cancer treatments (chemo, radiation) further lower Vitamin D
• Higher levels of vitamin D minimize many side-effects of cancer therapy
• High levels of vitamin D augment many chemotherapies
• High levels of vitamin D augment cancer immunotherapies
• High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
• Some cancers deactivate the vitamin D receptor

Example Vitamin D Life Studies

• Cancer and Vitamin D - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
• Metastatic Cancer probably reduced by vitamin D - many studies
• Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
• Radiation therapy, used to treat some cancers, causes less damage if use Vitamin D (or Melatonin) – Aug 2022
• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Palliative care is helped by Vitamin D - many studies
• 4X less of one chemo needed after vitamin D receptor activation - June 2020

Breast Cancer

• Breast Cancer survivors with high vitamin D were 3.3 X less likely to have metastases – May 2023
• Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
• Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
• Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017