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Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022


Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID

Only CRP and NO were signifcantly changed by Mg

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60% of trials found that CRP was reduced by Mg

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Amount of NO increase - similar for the 3 trials

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Magnesium trials: type, duration, and amount

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.

In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.

In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
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12+ Vitamin D Life pages with NITRIC OXIDE in the title

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Items found: 12

Vitamin D Life pages with CRP in title (8 as of April 2022)

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Items found: 11

Vitamin D Life - Inflammation category starts with

171 items total

Example studies

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Vitamin D Life - Overview Magnesium and vitamin D venn relationship of Mg and Vit D


See also: Mg and NO on PubMed


Vitamin D Life - 30 most-recently changed items in the Magnesium Category

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Id Page Hits Last modification Creator Categories
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6743 Vitamin D Cofactors in a nutshell 86576
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15065 Magnesium Pidolate may be a good form to reduce headaches – Aug 2020 196
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3437 Headache 64723
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13948 Magnesium reduces hypertension - FDA allows claim - Jan 2022 822
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7277 Magnesium increases Vitamin D and decreases mortality - 2013 8890
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14220 Co-factors increase Vitamin D response for the GRH cohort - Jan 2023 2558
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14950 After stroke, 40% less likely to die if 400 mg of Magnesium daily - Oct 2023 509
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2431 100 mg more Magnesium in water associated with 8 percent reduction in stroke – Feb 2012 5716
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14815 How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 883
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5116 Magnesium and Vitamin D 70496
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Created by admin. Last Modification: Friday September 22, 2023 13:24:17 GMT-0000 by admin. (Version 17)

Attached files

ID Name Comment Uploaded Size Downloads
17989 Mg increase NO.jpg admin 27 Jun, 2022 20.36 Kb 225
17988 statistically significant.jpg admin 27 Jun, 2022 19.69 Kb 243
17459 CRP Mg table.jpg admin 20 Apr, 2022 143.38 Kb 371
17457 CRP reduction by Magnseium.jpg admin 20 Apr, 2022 28.45 Kb 302
17456 Magnesium resuces Inflammation.pdf admin 20 Apr, 2022 989.96 Kb 227