Table of contents
- L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study
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- Vitamin D Life - Mortality starts category contains
- Mortaility studes - Dr. Grant, etc.
- Vitamin D Life -
25 studies in both categories Cardiovascular and Mortality L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study
BMC Medicine volume 20, Article number: 308 (2022) https://doi.org/10.1186/s12916-022-02510-1
Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen & Ben He
Background
The relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among American adults with OA.Methods
This study included 2556 adults with OA from the National Health and Nutrition Examination Survey (2001–2014). Death outcomes were ascertained by linkage to National Death Index (NDI) records through 31 December 2015. Cox proportional hazards model and two-piecewise Cox proportional hazards model were used to elucidate the nonlinear relationship between serum 25(OH)D concentrations and mortality in OA patients, and stratified analyses were performed to identify patients with higher mortality risk.Results
During 16,606 person-years of follow-up, 438 all-cause deaths occurred, including 74 cardiovascular disease (CVD)-related and 78 cancer deaths. After multivariable adjustment, lower serum 25(OH)D levels were significantly and nonlinearly associated with higher risks of all-cause and CVD mortality among participants with OA. Furthermore, we discovered L-shaped associations between serum 25(OH)D levels and all-cause and CVD mortality, with mortality plateauing at 54.40 nmol/L for all-cause mortality and 27.70 nmol/L for CVD mortality. Compared to participants with 25(OH)D levels below the inflection points, those with higher levels had a 2% lower risk for all-cause mortality (hazard ratio [HR] 0.98, 95% confidence interval [CI] 0.96–0.99) and 17% lower risk for CVD mortality (HR 0.83, 95% CI 0.72–0.95).Conclusions
Nonlinear associations of serum 25(OH)D levels with all-cause and CVD mortality were observed in American patients with OA. The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease, but this needs to be confirmed in large clinical trials.
 Download the PDF from Vitamin D LifeVitamin D Life - Osteoarthritis category contains
59 items total - see also Overview Osteoporosis and vitamin D Overview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020Vitamin D Life - Mortality starts category contains
People die sooner if they have low vitamin D
There are
click on image for details312 articles in Mortality category Mortaility studes - Dr. Grant, etc.
Mortality
- Dr. Grant on vitamin D and mortality in Vitamin D Life
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
- 29 X more likely to die of COVID if less than 20 ng of Vitamin D - March 2022
Vitamin D Life -
25 studies in both categories Cardiovascular and Mortality This list is automatically updated
- Risk of Cardiovascular death decreased 5X (lowest to highest Vitamin D level)- Feb 2024
- Low Vitamin D associated with CHD, stroke, death, etc, (Mendelian analhysis) - Dec 2021
- Death rates of Cardiovascular patients keep decreasing until 90 nmol of Vitamin D - May 2023
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
People with Osteoarthritis who took a lot of vitamin D had a nice side-effect – half the death rate – Sept 20221410 visitors, last modified 22 Sep, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 18465 OA mortality.jpg admin 22 Sep, 2022 45.22 Kb 172 18464 OA table.jpg admin 22 Sep, 2022 26.11 Kb 161 18463 OA plus D results_CompressPdf.pdf admin 22 Sep, 2022 232.73 Kb 129