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Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017

Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium.

PLoS One. 2017 Feb 16;12(2):e0170791. doi: 10.1371/journal.pone.0170791. eCollection 2017.

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Gaksch M1, Jorde R2, Grimnes G2, Joakimsen R2, Schirmer H3, Wilsgaard T4, Mathiesen EB2, Njølstad I4, Løchen ML4, März W5,6,7, Kleber ME5,8, Tomaschitz A9,10,11, Grübler M1,9,12, Eiriksdottir G13, Gudmundsson EF13, Harris TB14, Cotch MF15, Aspelund T13,16, Gudnason V13,16, Rutters F17, Beulens JW17,18, van 't Riet E17, Nijpels G17, Dekker JM17, Grove-Laugesen D19, Rejnmark L19, Busch MA20, Mensink GB20, Scheidt-Nave C20, Thamm M20, Swart KM17, Brouwer IA21, Lips P22, van Schoor NM17, Sempos CT23, Durazo-Arvizu RA24, Škrabáková Z25, Dowling KG25, Cashman KD25,26, Kiely M25,27, Pilz S1,17.

Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.

In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488.

We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, and <30 nmol/L were 1.15 (1.00-1.29), 1.33 (1.16-1.51), and 1.67 (1.44-1.89), respectively. We observed similar results for cardiovascular mortality, but there was no significant linear association between 25(OH)D and cancer mortality. There was also no significantly increased mortality risk at high 25(OH)D levels up to 125 nmol/L.

In the first IPD meta-analysis using standardized measurements of 25(OH)D we observed an association between low 25(OH)D and increased risk of all-cause mortality. It is of public health interest to evaluate whether treatment of vitamin D deficiency prevents premature deaths.

Table 3.

Adjusted hazard ratio of death from cardiovascular causes (95% CI) by standardized 25-hydroxyvitamin D concentrations in nmol/L in competing risk analysis for full database without the New Hoorn Study [simplified and augmented by Vitamin D Life]

Category<30 nmol/L30–4040–5050–7575–100100>100
Sample size, n271628534638107172648-753
Deaths, n397257377663100-16
Death. %15%9%17% 6%4%-2%
Model 1aHazard Rate3.181.99 1.721.351.000.95
Model 2bHazard Rate3.101.93 1.691.341.000.95
Model 3cHazard Rate2.541.74 1.681.381.000.91
Model 4dHazard Rate2.211.61 1.651.371.000.92

It appears that a person is at least 5 times more likely to not die of cardiovascular problems if he has a high level of vitamin D

German language comment on this and previous mortality studies

A few of the many previous studies in Vitamin D Life which have had a similar conclusion:

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Vitamin D Life - Longevity and healthspan increased by Vitamin D - many studies

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7749 Mortality HR.jpg admin 01 Mar, 2017 25.49 Kb 3366
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