Cognitive Function and Vitamin D Status in the Chinese Hemodialysis Patients
Comput Math Methods Med. 2022 Sep 9;2022:2175020 doi: 10.1155/2022/2175020. eCollection 2022.
Jing Zhang 1 , Jun Hu 2 , Ru Zhou 1 , Yuzhen Xu 3
Objective: Vitamin D insufficiency and the cognitive function decline are both common in patients receiving hemodialysis (HD). The present study evaluated the relation between cognitive function and circulating vitamin D levels in HD patients in Wannan Medical College Affiliated Yijishan Hospital, China.
Methods: This study was conducted in 80 patients receiving HD in Wannan Medical College Affiliated Yijishan Hospital. To measure cognitive function, Montreal Cognitive Assessment-Basic (MoCA-B) Chinese Version was used. The 25-hydroxyvitamin D [25(OH)D], which is applied to assess vitamin D status, was tested. One-way ANOVA, Tukey post hoc test, and the correlation and regression analysis were used in this study.
Results: Based on the MoCA-B, cognitive function decline (the scores below 26) was present in 28 HD patients, accounting for 35% (28/80). The mean age of these patients is 50.5 ± 10.9 years old. The mean level of 25(OH)D was 16.1 ± 7.3 ng/ml in 80 HD patients. In univariate analysis, there was a significant relationship between MoCA-B score and serum 25(OH)D level (p < 0.05). The level of 25(OH)D was positively correlated with MoCA-B score (r = 0.312, p = 0.023), and the association was independent of demographic and clinical features.
Conclusions: Vitamin D insufficiency may contribute to cognitive function decline in HD patients. Serum level of 25(OH)D is an independent protective factor of cognitive function in the HD patients.
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