Sleep quality 6X worse after stroke if low vitamin D – July 2022

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Reduced serum vitamin D levels are associated with poor sleep quality in early stroke patients

Front Nutr. 2022 Jul 22 doi: 10.3389/fnut.2022.937867
Guiqian Huang 1 , Jiahao Chen 1 , Luqian Zhan 1 , Jingfang Long 1 , Yisi Lin 1 , Beilei Zhu 1 , Jincai He 1

Background: Poor sleep quality and vitamin D deficiency are common in stroke patients. Our aim was to evaluate the possible association between vitamin D and sleep quality in acute ischemic stroke (AIS) patients.

Methods: A total of 301 AIS patients were screened and completed 1-month follow-up. Serum 25-hydroxyvitamin D [25(OH)D] was used to assess the vitamin D status by a competitive protein-binding assay at baseline. All patients were divided into equal quartile according to the distribution of 25(OH)D. One month after stroke, sleep quality was evaluated by using Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaire; depression status was confirmed by 17-item Hamilton Depression Scale (HAMD).

Results: There were 89 (29.6%) AIS patients with poor sleep quality 1-month post-event. Within 24 h after admission, serum 25(OH)D levels were significantly lower in patients with poor sleep quality after stroke (P < 0.001). In the results of multivariate-adjusted logistic regression analysis, the odds ratio (OR) of poor sleep quality was 6.199 (95% CI, 2.066-18.600) for the lowest quartile of 25(OH)D compared with the highest quartile. In patients without depression, reduced 25(OH)D were still significantly associated with poor sleep quality (OR = 8.174, 95% CI = 2.432-27.473). Furthermore, 25(OH)D and HAMD score were combined to enhance the diagnostic accuracy of poor sleep quality, with the area under the receiver operating characteristic curve of 0.775.

Conclusion: Reduced serum levels of vitamin D at admission were independently and significantly associated with poor sleep quality at 1 month after stroke. Our findings suggested the combination of vitamin D and depression status could provide important predictive information for post-stroke sleep quality.
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Vitamin D Life - Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

• Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
• Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
• Ischemic stroke 17 X more likely if low vitamin D – April 2017
• Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
• Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014

Post-Stroke worse if low Vitamin D

• Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023
• Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
• Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
• Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
• Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
• Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
• Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019

Post-Stroke better if add Vitamin D

• Post-stroke Vitamin D supplementation helped in 11 ways – May 2023
• Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
• Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
• Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
• Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019

Post-Stroke better if Vitamin D actually gets to cells

• Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
• Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020

9 studies in both categories Depression and Stroke

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Vitamin D Life - Sleep category contains

97 items in sleep category

A few items in SLEEP category

• Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
• Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
• Sleep, Dr. Gominak and Vitamin D - several studies
• Restless Legs Syndrome dramatically reduced by vitamin D, etc
• On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
• Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
• The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
• The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
• Vitamin D for better sleep video - Dec 2021
• 5X increase in sleep problems in a decade in US Veterans
• Sleep Apnea and Vitamin D - many studies
• Melatonin and Vitamin D - many studies does much more than improve sleep

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Note: Many health problems are associated with low vitamin D and poor sleep