Psychiatric Genetics, Volume 31, Number 6, 22 October 2021, pp. 230-238(9)
https://doi.org/10.1097/YPG.0000000000000295 PDF is behind a $52 paywall
Wei, Yan-Xin; Liu, Bao-Peng; Qiu, Hui-Min; Zhang, Ji-Yu; Wang, Xin-Ting; Jia, Cun-Xian
Objective
Emerging evidence suggests that vitamin D might protect from attempted suicide. The study aimed to investigate the associations between single-nucleotide polymorphisms (SNPs) related to vitamin D levels identified in a large genome-wide association study and attempted suicide in rural China.
Methods
This 1:1 matched case–control study included altogether 510 suicide attempters and 510 community controls.
Genotypes of four target SNPs (
- DHCR7-rs12785878,
- CYP2R1-rs10741657,
- GC-rs2282679, and
- CYP24A1-rs6013897)
were determined, and a genetic risk score (GRS) was constructed to evaluate the combined effect of them. Demographic and psychological information was acquired through face-to-face interviews.
Results
The A allele of CYP24A1-rs6013897 was significantly associated with attempted suicide (OR = 1.27, 95% CI, 1.03–1.58, P = 0.029), even after adjusting for demographic and psychological confounders (adjusted OR = 1.53, 95% CI, 1.01–2.30, P = 0.043). The GRS analyses revealed a significantly higher risk of attempted suicide with a greater number of low vitamin D alleles (adjusted OR = 1.33, 95% CI, 1.13–1.58, P < 0.001).
Subgroup analyses stratified by sex indicated that the genetic associations were only significant among males with adjusted ORs of 3.77 (95% CI, 1.56–9.10) for the A allele of rs6013897 and 2.04 (95% CI, 1.32–3.17) for GRS.
Conclusions
Our findings identity CYP24A1-rs6013897 as a potential biomarker for attempted suicide and indicate that a genetic predisposition to lower vitamin D levels may contribute to attempted suicide. It suggests the possibility that vitamin D may have the preventive potential for attempted suicide.
Vitamin D Life pages with CYP24A1 in title
This list is automatically updated
Items found: 28
| Title | | Modified |
| CYP24A1 enzyme and Vitamin D | | 08 May, 2022 |
| Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1) – Oct 2021 | | 08 May, 2022 |
| Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021 | | 08 Dec, 2021 |
| 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012 | | 22 Jan, 2021 |
| Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020 | | 10 Jan, 2020 |
| Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019 | | 18 Nov, 2019 |
| Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019 | | 16 Nov, 2019 |
| Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 | | 15 Nov, 2019 |
| Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019 | | 15 Nov, 2019 |
| Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019 | | 07 Nov, 2019 |
| CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012 | | 16 May, 2019 |
| Hepatitis C 1.4X more likely if poor CYP24A1 gene – May 2019 | | 08 May, 2019 |
| Natural pregnancy 4X more likely if sperm had a lot of CYP24A1 – April 2019 | | 10 Apr, 2019 |
| Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 | | 31 Dec, 2018 |
| CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011 | | 31 Dec, 2018 |
| CYP24A1 enzyme and Vitamin D | | 31 Dec, 2018 |
| Maternal diabetes with poor Vitamin D gene (CYP24A1) increases risk of diabetes in female offspring by 40 percent – Jan 2018 | | 24 Jan, 2018 |
| Vitamin D gene (CYP24A1) changes decrease breast and pancreatic cancers – meta-analysis Nov 2017 | | 20 Dec, 2017 |
| Calcium problems associated with CYP24A1 (a Vitamin D gene) – Oct 2017 | | 08 Nov, 2017 |
| If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016 | | 07 Jun, 2017 |
| Rare mutation of gene (CYP24A1) results in Vitamin D accumulating in the body – Jan 2017 | | 23 Jan, 2017 |
| Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 | | 30 Mar, 2016 |
| Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015 | | 16 Nov, 2015 |
| Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012 | | 16 Nov, 2015 |
| Mutations in CYP24A1 gene (vitamin D) associated with kidney problems – Jan 2013 | | 16 Nov, 2015 |
| Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 | | 24 Feb, 2015 |
| Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 | | 26 Nov, 2014 |
| CYP24A1 gene, kidney disease, and vitamin D - May 2011 | | 02 Nov, 2012 |
Blood test does not notice when a poor CYP24A1 gene stops Vitamin D from getting to cells
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