Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials -A Meta-analysis
JAMA Cardiol. Published online June 19, 2019. doi:10.1001/jamacardio.2019.1870
Yup, <2,000 IU has virtually no detectable CV benefit, need 4,000+ IU
Other Cardiovascular Meta-analyses as of june 2019
Low Dose, No Benefit
- Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis Jan 2018
- Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
- 800 IU Vitamin D does not help heart – meta-analysis Aug 2011
High Dose, Yes Benefit
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019
Low Vitamin D, Cardiovascular problems
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease patients have low vitamin D levels – meta-analysis Oct 2015
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016
- Cardiovascular disease 50 % more likely if low vitamin D - meta-analysis Nov 2012
- Half as many heart deaths for those with high levels of vitamin D – meta-analysis Sept 2012
- Shift workers 23 percent more likely to have cardiovascular events – meta-analysis July 2012
Poor Vitamin D Genes, Cardiovascular Problems
Items in both categories Cardiovascular and Intervention are listed here:
- 50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014
- 50,000 IU of Vitamin D for 9 weeks was enough to restore blood levels (but not long enough to statistically improve CVD) – Aug 2018
- Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
- Heart Failure not helped by Vitamin D (several strange things about the trial) – RCT May 2017
- Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
- Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D – May 2015
- Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014
- Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
- Hearts responded to stress better after 5,000 IU of vitamin D for a month - March 2014
- More blood was pumped by those getting 800,000 IU of vitamin D after heart failure – RCT Oct 2013
- Chronic Heart Failure helped with 2,000 IU of vitamin D (PRA reduced) – RCT June 2013
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Download the PDF from Vitamin D Life
Titles of articles reporting on this poor study
JAMA has a great press release system
The Demise of Vitamin D for Cardiovascular Prevention = JAMA editorial
Vitamin D may not help your heart - Medical Xpress
No cardiovascular benefit from vitamin D supplementation
Vitamin D Use Does Not Reduce Risk of Cardiovascular Disease
New study suggests Vitamin D has no impact on heart health
Vitamin D Supplements Not Associated with Lower CVD Risks
Vitamin D supplementation fails to reduce major adverse CV events
Vitamin D for CV Risk? Think Twice, Meta-analysis Confirms
Vitamin D supplements may not reduce the risk of cardiovascular disease
Forget Vitamin D Supplements for Heart Disease
Meta-Analysis Does Not Link Vitamin D Supplements, Drop in MACE
Forget the vitamin D when it comes to CVD
Vitamin D does NOT prevent heart disease, study finds
Study: Vitamin D Supplements Don’t Lower Risk For Heart Disease
Popping a vitamin D supplement for heart benefits? It might not help at all
Study Disproves Common Belief in Vitamin "D"!
Lack of effect: Massive meta-analysis reports no heart benefits for vitamin D supplements
Vitamin D does zilch for CVD prevention: meta-analysis
Vitamin D not protective against cardiovascular events
21 trials
45% used only 100-1,000 IU
14% dosing interval was too long (3+ months)
14% did not use Vitamin D
Short URL= is.gd/CardioMeta
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