Correlation Analysis between Serum Vitamin D Levels and Lower Extremity Macrovascular Complications in Individuals with Type 2 Diabetes Mellitus
Journal of Diabetes Research, Volume 2019, Article ID 4251829, https://doi.org/10.1155/2019/4251829
NGR: normal glucose regulation; T2DM: Mi: = mild; Mo = moderate; Se = severe
The severity of many diseases is associated with lower levels of Vitamin D
Supplementing with Vitamin D will sometimes treat the disease, but will always reduce the incidence of other diseases
- Diabetic Foot Ulcer 3.2 X or 3.6 X more likely if low vitamin D – meta-analyses 2019
- Diabetic Foot Ulcer patients had low vitamin D (half had less than 10 ng) – July 2018
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
454 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 49 ; Meta-analysis 28 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 34 ; Omega-3 10 ; Vitamin D Receptor 18 ; Genetics 10 ; Magnesium 18 Click here to see details Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
A diabetic foot severity grade from the web
Download the PDF from Vitamin D Life
Mengxue Yang yangmengx123 at 163.com,1,2 Jun Liu,1 Xue Zhou,2 Heyuan Ding,1 Jie Xu,3 Bo Yang,2 Bowen Sun,2 Dandan Xiao,2 Jie Yu,3 and Qihai Gong4- 1Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
- 2Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China
- 3School of Public Health, Zunyi Medical University, Zunyi 563000, China
- 4Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China
The correlation between serum 25-hydroxy vitamin D (25(OH)D) levels and lower extremity atherosclerotic disease and the predictive value of 25(OH)D for early-stage lower extremity atherosclerotic disease in patients with type 2 diabetes mellitus (T2DM) were explored. In total, 620 subjects (590 T2DM patients and 30 healthy subjects) completed a questionnaire. All subjects were divided into four groups according to serum 25(OH)D concentration quartile: Q1 (<12.18 ng/ml), Q2 (12.18~20.65 ng/ml), Q3 (20.65~31.97 ng/ml), and Q4 (>31.97 ng/ml). Participants were also divided into four groups based on the degree of lower extremity arteriostenosis:
- A1 (T2DM),
- A2 (T2DM with mild lower extremity vascular lesions (LEVL)),
- A3 (T2DM with moderate LEVL), and
- A4 (T2DM with severe LEVL).
The incidence of lower extremity artery plaque was significantly higher in groups Q1 and Q2 than in group Q4 (both p <.0.05 ). The concentration of 25(OH)D was significantly lower in group A4 than in groups A1 and A2. Pearson correlation analysis revealed that the degree of lower extremity vascular stenosis was positively correlated with age, smoking, and HbA1c, CRP, and LDL-C levels and negatively correlated with 25(OH)D concentrations. Logistic regression analysis demonstrated that 25(OH)D concentrations exerted a protective effect against LEVL in T2DM patients. Serum 25(OH)D concentrations may be correlated with the incidence of macrovascular disease in T2DM patients. A low serum 25(OH)D concentration is an independent risk factor for lower extremity vascular pathological changes and acts as a prognostic index for lower extremity atherosclerotic disease.
The worse the diabetic foot, the lower the vitamin D level – Nov 2019Printer Friendly PDF this page! Follow this page for updates1499 visitors, last modified 28 Nov, 2019, This page is in the following categories (# of items in each category)Diabetes454 Attached files
ID Name Comment Uploaded Size Downloads 13056 Diabetic foot grade.jpg admin 28 Nov, 2019 11:31 35.67 Kb 69685 13055 T2DM lower.jpg admin 28 Nov, 2019 10:58 20.22 Kb 450 13054 Lower Extremity T2DM.pdf PDF 2019 admin 28 Nov, 2019 10:58 1.59 Mb 155 See any problem with this page? Report it (FINALLY WORKS) - Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.