David Buchebner, Lund University Sweden Dec 2017
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Fracture 4.8 X more likely if low vitamin D, Falls 2.7 X were more likely if low D – Oct 2017
- ALL of the top 10 health problems of women are associated with low vitamin D
- Save 2 billion dollars annually in fractures if take Vitamin D and Calcium – Frost and Sullivan Sept 2013
- 80 percent of the characteristics of frailty associated with low vitamin D – May 2013
Falls and Fractures category contains the following summary
219 items in FALLS and FRACTURES - see also Overview Seniors and Vitamin D
- Overview Fractures and Falls and Vitamin D
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
Hip fracture
- Search Vitamin D Life for "HIP FRACTURE" 191 items not in PDF as of July 2020
- A call to action: Vitamin D for hip fracture – Holick July 2020
- Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020
- 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
- Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
- Fracture risk 40 percent higher risk if low Vitamin D - June 2019
- 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
 Download the PDF from Vitamin D LifeLow Vitamin D ==> More fractures (3 paths)
Low Vitamin D ==> Low bone density
Low Vitamin D ==> die sooner
Vitamin D (25OHD) is essential for maintaining calcium homeostasis and inadequate levels have been associated with negative musculoskeletal as well as extraskeletal effects. Individuals at especially high risk of developing hypovitaminosis D are the elderly. The aim of this thesis was to investigate the association between 25OHD insufficiency (25OHD <50 nmol/L) and fractures, frailty and mortality. Additionally, we described the normal distribution of parathyroid hormone (PTH) in older women in relation to 25OHD and kidney function (eGFR) and investigated whether PTH was an independent predictor of frailty and mortality.
Data was obtained from women participating in the Malmö Osteoporotic Risk Assessment Cohort (OPRA). This cohort consists of 1044 community-dwelling women, aged 75 years, who were followed prospectively for more than 15 years with reevaluations at ages 80 and 85 years. Blood biochemistry including 25OHD, PTH and eGFR was available at all time points. Information on fractures and mortality was continuously registered and a frailty index was constructed.
Women with 25OHD levels <50 nmol/L, sustained between ages 75 and 80 years, had a higher 10-year risk of suffering a major osteoporotic fracture compared to women who maintained 25OHD levels ≥50 nmol/L (HR=1.8 [1.2-2.8], p=0.008). Mortality risk within 10 years of follow-up was significantly higher in 25OHD insufficient women compared to those with 25OHD >75 nmol/L (75y: HR=1.4 [1.0-1.9], p=0.04 and 80y: HR=1.8, 95%CI=1.3-2.4, p<0.001). This increased risk remained after adjustment for smoking, diagnosis of osteoporosis and other comorbidities (at age 80).Between ages 75 and 80 years, PTH increased in 60% of all women (n=390) but increases of up to 50% above baseline values (64%; n=250) still resulted in PTH levels within the normal reference range (NRR), accompanied by lower 25OHD (74 vs 83 nmol/L, p=0.001). Only when increases were >50% was PTH elevated beyond the NRR. Here, a pronounced decline in kidney eGFR (56 vs 61 mL/min/1.73 m2, p=0.002) was found, despite no further decline in 25OHD.
At age 85 years, half of the women had stable or decreased PTH levels (51%; n=169). PTH levels above NRR were not independently associated with mortality.
At both ages 75 and 80, women with 25OHD <50 nmol/L were more frail compared to 25OHD sufficient women (0.23 vs 0.18; p<0.001 and 0.32 vs 0.25; p=0.001).
Accelerated progression of frailty was not associated with lower 25OHD. Variables within the frailty-index that were associated with 25OHD, were those related to muscle strength and function. PTH was not independently associated with frailty
In conclusion, 25OHD levels <50 nmol/L were associated with significant impairments of the musculoskeletal system (fractures, frailty) and predicted all-cause mortality in independently living older women. Parathyroid hormone was inversely correlated to 25OHD and eGFR but was not an independent predictor of frailty or mortality.
Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 20172319 visitors, last modified 27 Jan, 2018, This page is in the following categories (# of items in each category)Seniors341 Bone - Health 269 Mortality and D 207 Falls and Fractures 219 Women 139 Attached files
ID Name Comment Uploaded Size Downloads 8811 Thesis mortality.jpg admin 25 Nov, 2017 13:29 22.10 Kb 524 8810 high bone density associated with higher Vit D.jpg admin 25 Nov, 2017 13:20 26.85 Kb 420 8809 Vitamin D In Older Women- thesis-min.pdf PDF 2017 admin 25 Nov, 2017 13:19 1.44 Mb 414 See any problem with this page? Report it (FINALLY WORKS)