Loading...
 
Toggle Health Problems and D

Vitamin D associated with reduced T-cell attacks in Multiple Sclerosis – Sept 2012

Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients.

MC Neurol. 2012 Sep 24;12:103. doi: 10.1186/1471-2377-12-103.
Grau-López L, Granada ML, Raïch-Regué D, Naranjo-Gómez M, Borràs-Serres FE, Martínez-Cáceres E, Ramo-Tello C.
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, Badalona, Barcelona, 08916, Spain. laiagrlo at gmail.com

BACKGROUND: Low levels of plasma 25-hydroxyvitaminD (25(OH)D) are associated with a higher incidence of multiple sclerosis (MS) due to the immune suppressive properties of vitamin D.The aim of this study was to determine the correlation between plasma 25(OH)D concentrations and clinical and immunological variables in a cohort of multiple sclerosis patients.

METHODS: Plasma 25(OH)D concentrations were evaluated in summer and winter in 15 primary progressive MS (PPMS) patients, 40 relapsing- remitting MS (RRMS) patients and 40 controls (HC). Protocol variables included demographic and clinical data, radiological findings and immunological variables (oligoclonal bands, HLADR15 and T-lymphocyte proliferation to a definite mix of 7 myelin peptides).

RESULTS: During the winter, plasma concentrations were significantly lower in RRMS patients compared to HC, whereas no differences were found in summer. No relationships were found between plasma 25(OH)D concentrations and clinical or radiological variables. RRMS patients with a positive T-cell proliferation to a mix of myelin peptides (n = 31) had lower 25(OH)D concentrations.

CONCLUSIONS: 25(OH)D is an immunomodulatory molecule that might have a regulatory role in T-cell proliferation to myelin peptides in RRMS patients.

PMID: 23006125
Image


PDF is attached at the bottom of this page


See also Vitamin D Life

Attached files

ID Name Comment Uploaded Size Downloads
2053 T-cell MS.jpg admin 01 Feb, 2013 20:53 30.25 Kb 875
2052 T-cell MS.pdf PDF admin 01 Feb, 2013 20:53 268.16 Kb 524
See any problem with this page? Report it (FINALLY WORKS)