Loading...
 
Toggle Health Problems and D

7000 IU (50000 weekly) increased vitamin D levels in breast cancer patients – Mar 2011

The effect of various vitamin D supplementation regimens in breast cancer patients.

Breast Cancer Res Treat. 2011 Mar 8.
Peppone LJ, Huston AJ, Reid ME, Rosier RN, Zakharia Y, Trump DL, Mustian KM, Janelsins MC, Purnell JQ, Morrow GR.
Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 704, Rochester, NY, 14642, USA, luke_peppone at urmc.rochester.edu.

Vitamin D deficiency in the patients treated for breast cancer is associated with numerous adverse effects (bone loss, arthralgia, and falls).
The first aim of this study was to assess vitamin D status, determined by 25-OH vitamin D levels, among women diagnosed with breast cancer according to demographic/clinical variables and bone mineral density (BMD).

The second aim of this study was to evaluate the effect of daily low-dose and weekly high-dose vitamin D supplementation on 25-OH vitamin D levels.
This retrospective study included 224 women diagnosed with stage 0-III breast cancer who received treatment at the James P. Wilmot Cancer Center at the University of Rochester Medical Center.

Total 25-OH vitamin D levels (D(2) + D(3)) were determined at baseline for all participants.
Vitamin D deficiency was defined as a 25-OH vitamin D level < 20 ng/ml, insufficiency as 20-31 ng/ml, and sufficiency as ?32 ng/ml.

BMD was assessed during the period between 3 months before and 6 months following the baseline vitamin D assessment.

Based on the participants' baseline levels, they received either

  • no supplementation,
  • low-dose supplementation (1,000 IU/day), or
  • high-dose supplementation (?50,000 IU/week),

and 25-OH vitamin D was reassessed in the following 8-16 weeks.

Approximately 66.5% had deficient/insufficient vitamin D levels at baseline.
Deficiency/insufficiency was more common among non-Caucasians, women with later-stage disease, and those who had previously received radiation therapy (P < 0.05).
Breast cancer patients with deficient/insufficient 25-OH vitamin D levels had significantly lower lumbar BMD (P = 0.03).
Compared to the no-supplementation group, weekly high-dose supplementation significantly increased 25-OH vitamin D levels, while daily low-dose supplementation did not significantly increase levels. Vitamin D deficiency and insufficiency were common among women with breast cancer and associated with reduced BMD in the spine.
Clinicians should carefully consider vitamin D supplementation regimens when treating vitamin D deficiency/insufficiency in breast cancer patients.

PMID: 21384167

PDF is attached at the bottom of this page
- - - - - - - - - - - - - - - - - - - -

See also Vitamin D Life

Attached files

ID Name Comment Uploaded Size Downloads
1475 Breast Cancer - 2011.pdf PDF admin 22 Jul, 2012 14:40 330.80 Kb 886
See any problem with this page? Report it (FINALLY WORKS)