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Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015

Medical Hypothesis DOI: http://dx.doi.org/10.1016/j.mehy.2014.12.028
Michael S. Donaldson mdonaldson at hacres.com
Hallelujah Acres, 1733 Cutler Way, Zillah, WA 98953, United States
Received: July 21, 2014; Accepted: December 28, 2014; Published Online: January 19, 2015

 Download the PDF from ResearchGate via Vitamin D Life

Though age-related prostate enlargement is very common in Western societies, and the causes of benign prostate hyperplasia, BPH, have been diligently sought after, there is no biological, mechanistic explanation dealing with the root causes and progression of this very common disorder among men. All treatments to date are based on symptomatic relief, not a fundamental understanding of the cause of the disease. However, recent advances have shown that even subclinical varicoceles, which are more common than generally realized, cause retrograde blood flow from the testes past the prostate gland causing over a 130-fold increase in free testosterone in the veins near the prostate. By treating the varicoceles via embolization of the internal spermatic vein and its communicating and connected vessels the prostate enlargement can be reversed with corresponding symptomatic relief. So, varicose veins in the pampiniform venous plexus, varicoceles, are the direct cause of BPH. But what causes varicoceles?

Recent research has uncovered the role of vitamin K in the calcification of varicose veins as well as a role in the proliferation of smooth muscle cells in the media layer of the vein wall. Vitamin K is intimately involved in the formation of varicose veins. The hypothesis is that poor prostate health is essentially a vitamin K insufficiency disorder. By providing vitamin K in the right form and quantity, along with other supporting nutrients and phytochemicals, it is likely that excellent prostate health can be extended much longer, and perhaps poor prostate health can be reversed. A protective role for vitamin K with respect to advanced prostate cancer was already found in the Heidelberg cohort of the EPIC study. This hypothesis can be further evaluated in studies examining the connection between vitamin K and varicoceles, and also by examining the connection between varicoceles and benign prostate hyperplasia. If this hypothesis is found to be true, management of prostate health will be radically altered. Rather than focusing on prostate health as a hormonal imbalance, prostate enlargement will be seen as a result of poor health of the veins in general and the internal spermatic veins in particular. Factors which promote the health of the veins will become a greater focus of research, including the role of vitamin K. Finally, the emerging understanding of the cause of BPH will empower men to take care of their bodies so they can enjoy much better health through their entire lifespan.

References

  1. Roehrborn, C.G. Benign prostatic hyperplasia: an overview. Rev Urol. 2005;7:S3–S14. PubMed
  2. Hammarsten, J.Högstedt, B.Holthuis, N.Mellström, D. Components of the metabolic syndrome-risk factors for the development of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 1998;1:157–162. CrossRef | PubMed
  3. Roehrborn, C.G. 5α-reductase inhibition in the treatment of LUTS and BPH: update and importance of dual inhibition of Types 1 and 2. Rev Urol. 2004;6:S1–S2. PubMed
  4. Zeng, Q.-S.Xu, C.-L.Liu, Z.-Y.Wang, H.-Q.Yang, B.Xu, W.-D. et al, Relationship between serum sex hormones levels and degree of benign prostate hyperplasia in Chinese aging men. Asian J Androl. 2012;14:773–777. CrossRef | PubMed | Scopus (3)
  5. Gat, Y.Gornish, M.Heiblum, M.Joshua, S. Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment. Andrologia. 2008;40:273–281. CrossRef | PubMed | Scopus (24)
  6. Gat, Y.Gornish, M. Reversal of benign prostate hyperplasia by super-selective intraprostatic androgen deprivation therapy. Eur Urol Rev. 2009;4:10–14.
  7. Comhaire, F.Kunnen, M. Selective retrograde venography of the internal spermatic vein: a conclusive approach to the diagnosis of varicocele. Andrologia. 1976;8:11–24. CrossRef | PubMed
  8. Elsharawy, M.A.Naim, M.M.Abdelmaguid, E.M.Al-Mulhim, A.A. Role of saphenous vein wall in the pathogenesis of primary varicose veins. Interact Cardiovasc Thorac Surg. 2007;6:219–224. CrossRef | PubMed | Scopus (32)
  9. Oklu, R.Habito, R.Mayr, M.Deipolyi, A.R.Albadawi, H.Hesketh, R. et al, Pathogenesis of varicose veins. J Vasc Interv Radiol. 2012;23:33–39. Abstract | Full Text | Full Text PDF | PubMed | Scopus (13)
  10. Raffetto, J.D.Khalil, R.A. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebol Venous Forum R Soc Med. 2008;23:85–98. CrossRef | PubMed | Scopus (86)
  11. Cario-Toumaniantz, C.Boularan, C.Schurgers, L.J.Heymann, M.-F.Le Cunff, M.Léger, J. et al, Identification of differentially expressed genes in human varicose veins: involvement of matrix Gla protein in extracellular matrix remodeling. J Vasc Res. 2007;44:444–459. CrossRef | PubMed | Scopus (26)
  12. Nimptsch, K.Rohrmann, S.Linseisen, J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European prospective investigation into cancer and nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2008;87:985–992. PubMed
  13. Nimptsch, K.Rohrmann, S.Nieters, A.Linseisen, J. Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case–control study in the Heidelberg cohort of the european prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18:49–56. CrossRef | PubMed | Scopus (11)
  14. Schurgers, L.J.Spronk, H.M.H.Soute, B.A.M.Schiffers, P.M.DeMey, J.G.R.Vermeer, C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood. 2007;109:2823–2831. CrossRef | PubMed | Scopus (89)
  15. Geleijnse, J.M.Vermeer, C.Grobbee, D.E.Schurgers, L.J.Knapen, M.H.J.van der Meer, I.M. et al, Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134:3100–3105. PubMed
  16. Gat, Y.Bachar, G.N.Zukerman, Z.Belenky, A.Gornish, M. Varicocele: a bilateral disease. Fertil Steril. 2004;81:424–429. Abstract | Full Text | Full Text PDF | PubMed | Scopus (71)
  17. Gliński, W.Chodynicka, B.Roszkiewicz, J.Bogdanowski, T.Lecewicz-Toruń, B.Kaszuba, A. et al, The beneficial augmentative effect of micronised purified flavonoid fraction (MPFF) on the healing of leg ulcers: an open, multicentre, controlled, randomised study. Phlebology. 1999;14:151–157. CrossRef
  18. Jantet, G. Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assessment and quality of life improvement with micronized flavonoids. Angiology. 2002;53:245–256. CrossRef | PubMed
  19. Underland, V.Saeterdal, I.Nilsen, E.S. Cochrane summary of findings: horse chestnut seed extract for chronic venous insufficiency. Glob Adv Health Med. 2012;1:122–123. CrossRef | PubMed
  20. Koch, R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002;16:S1–S5. CrossRef | PubMed
  21. Petrassi, C.Mastromarino, A.Spartera, C. PYCNOGENOL in chronic venous insufficiency. Phytomed Int J Phytother Phytopharm. 2000;7:383–388.
  22. Levinger, U.Gornish, M.Gat, Y.Bachar, G.N. Is varicocele prevalence increasing with age?. Andrologia. 2007;39:77–80. CrossRef | PubMed | Scopus (30)
  23. Canales, B.K.Zapzalka, D.M.Ercole, C.J.Carey, P.Haus, E.Aeppli, D. et al, Prevalence and effect of varicoceles in an elderly population. Urology. 2005;66:627–631. Abstract | Full Text | Full Text PDF | PubMed | Scopus (31)
  24. Feskanich, D.Weber, P.Willett, W.C.Rockett, H.Booth, S.L.Colditz, G.A. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr. 1999;69:74–79. PubMed
  25. Apalset, E.M.Gjesdal, C.G.Eide, G.E.Tell, G.S. Intake of vitamin K1 and K2 and risk of hip fractures: the Hordaland health study. Bone. 2011;49:990–995. Abstract | Full Text | Full Text PDF | PubMed | Scopus (11)
  26. Beulens, J.W.J.Bots, M.L.Atsma, F.Bartelink, M.-L.E.L.Prokop, M.Geleijnse, J.M. et al, High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203:489–493. Abstract | Full Text | Full Text PDF | PubMed | Scopus (57)
  27. Juanola-Falgarona, M.Salas-Salvadó, J.Martínez-González, M.Á.Corella, D.Estruch, R.Ros, E. et al, Dietary intake of Vitamin K is inversely associated with mortality risk. J Nutr. 2014;144:743–750. CrossRef | PubMed
  28. Bittles, M.A.Hoffer, E.K. Gonadal vein embolization: treatment of varicocele and pelvic congestion syndrome. Semin Interv Radiol. 2008;25:261–270. CrossRef | PubMed | Scopus (6)

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