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Uterine Fibroids (uterine leiomyoma, need hysterectomy) 1.9 more likely if a Vitamin D receptor problem – Sept 2015

Egyptian Journal of Medical Human Genetics, doi:10.1016/j.ejmhg.2015.08.007
Shirin Shahbazi,

Evidences are growing toward an inhibitory role of vitamin D3 in uterine leiomyoma pathogenesis. Uterine leiomyoma commonly affects women of reproductive age and is referred to as one of the most common indications for hysterectomy, worldwide. The effects of vitamin D are mediated through the vitamin D receptor. A single nucleotide polymorphism of the VDR gene results in longer protein with decreased activity. The present study has focused on the distribution of FokI polymorphism in Iranian patients with uterine leiomyoma. Using the PCR-RFLP method 45 cases and 53 controls were assessed. The results demonstrated a correlation between VDR TT genotype and uterine leiomyoma by Odds Ratio of 1.886 (CI, .767–4.640). The examination of heterozygous CT genotype also showed the same result by Odds Ratio of 1.875 (CI, .629–5.590).
This study lends support for an increased risk of uterine leiomyoma associated with the VDR rs2228570 polymorphism. To the best of our knowledge this is the first report regarding VDR FokI polymorphism in leiomyoma patients.
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See also - web

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids Oct 2020
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Give many UF risk factors for testing Vitamin D levels.
Recommends a paultry 2,000 IU of vitamin D (with no loading dose)
No mention of gene problems
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For those with gene problems, generally just need more vitamin D

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Items in both categories Women and Vitamin D Receptor are listed here:

Attached files

ID Name Comment Uploaded Size Downloads
14476 Uterine Fibroids.pdf PDF 2020 admin 28 Oct, 2020 11:59 408.15 Kb 5
5910 Uterine fibroids.jpg admin 12 Sep, 2015 20:56 27.59 Kb 6977
5909 VDR hysterectomy.pdf PDF 2015 admin 12 Sep, 2015 20:56 640.12 Kb 877
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