Calcitriol and cancer therapy: A missed opportunity
Bone Reports. online 13 June 2018. https://doi.org/10.1016/j.bonr.2018.06.002
Donald L. Trump,
- How active vitamin D (Calcitriol) deals with cancer – June 2015
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Breast Cancer inhibited by Vitamin D and Calcitriol – mouse studies provide insight – Aug 2015
- Calcitriol category listing has
46 items along with related searches Cancer category starts with the following
- Cancer
211 items Overview Cancer and vitamin D - After Cancer Diagnosis
84 items - Bladder Cancer
25 items - Breast Cancer
223 items Overview Breast Cancer and Vitamin D - Colon Cancer
116 items Overview Cancer-Colon and vitamin D - Leukemia
16 items - Liver Cancer
14 items - Lung Cancer
49 items Overview Lung cancer and vitamin D - Lymphoma Cancer
22 items - Other Cancer
56 items - Ovarian Cancer
21 items - Pancreatic Cancer
55 items - Prostate Cancer
93 items Prostate Cancer and Vitamin D studies - Skin Cancer
110 items Overview Suntans melanoma and vitamin D - Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
15 articles - Breast Cancer and VDR
15 articles - Colon Cancer and VDR
9 articles - Prostate Cancer and VDR
6 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation
Items in both categories Calcitriol and Cancer are listed here:
- Active Vitamin D level should not be used for Prospective Studies of Cancer – Aug 2018
- Active vitamin D appears to treat cancer – more studies needed – June 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Cancer treated better when active vitamin d (calcitriol) is inside of PLGA nanoparticles – June 2015
- How active vitamin D (Calcitriol) deals with cancer – June 2015
Note: does not include any of the Cancer subcategories, such as Breast Cancer
Highlights
- __Studies in the 1970s and 1980s revealed that vitamin D compounds:
- had cancer prevention properties in animal models of carcinogen-induced tumors__
•**that the vitamin D receptor was expressed in many tissues and tumors arising from those tissues
•**that vitamin D compounds can slow the growth of tumor cells in vitro
•Numerous epidemiologic studies note the association between low vitamin D levels and cancer occurrence and outcome
•Thousands of 1,25dihydroxycholecalciferol (calcitriol) analogues have been synthesized seeking more effective or less toxic compounds
• Calcitriol suppresses the growth of tumors in vitro and in vivo by numerous mechanisms
• Calcitriol potentiates the anticancer effects of numerous cancer chemotherapy agents
• No analogue has been shown to have superior in vivo or clinical antitumor activity at equitoxic doses compared to calcitriol
• Many clinical trials in cancer patients have been done to define safety and efficacy of calcitriol and analogues
• While several trials suggest clinical benefit, no clearly positive trials have been done
• Two randomized trials of calcitriol + chemotherapy (docetaxel) in men with prostate cancer entered >1150 patients:
• These trials did not adhere to principles of optimal trial design (choice of optimal dose of drug and balanced randomization)
• Preclinical data strongly support the role of calcitriol or analogues in cancer therapy
• The failure to execute on these findings is a missed opportunityThe vitamin D receptor is expressed in most tissues of the body – and the cancers that arise from those tissues. The vitamin D signaling pathway is active in those tissues and cancers. This is at least consistent with the hypothesis that perturbing this signaling may have a favorable effect on the genesis and growth of cancers. Epidemiologic data indicate that vitamin D signaling may be important in the initiation and outcome of a number of types of cancer. Many studies have shown that calcitriol (1,25 dihydroxycholecalciferol) and other vitamin D compounds have antiproliferative, pro-apoptotic, anti-cell migration and antiangiogenic activity in a number of preclinical studies in many different cancer types. Unfortunately, the assessment of the activity of calcitriol or other vitamin D analogues in the treatment of cancer, as single agents or in combination with other anticancer agents has been stymied by the failure to adhere to commonly accepted principles of drug development and clinical trials conduct.
Active vitamin D appears to treat cancer – more studies needed – June 20181639 visitors, last modified 17 Jun, 2018, - Breast Cancer and VDR
- After Cancer Diagnosis
- Cancer