Circulating 25-Hydroxyvitamin D Concentrations Are Correlated With Cardiometabolic Risk Among American Black and White Adolescents Living in a Year-Round Sunny Climate.
Diabetes Care. 2012 Mar 12.
Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J, Gutin B, Houk C, Zhu H, Dong Y.
Internal Medicine, Department of Medicine, Georgia Health Sciences University, Augusta, Georgia.
OBJECTIVE: Low vitamin D status is common among healthy black and white adolescents residing at southern U.S. latitudes with a year-round sunny climate.
Thus we aimed to study the relationships between circulating 25-hydroxyvitamin D 25(OH)D and cardiometabolic risk factors in this population.
RESEARCH DESIGN AND METHODS: 25(OH)D concentrations were measured with liquid chromatography tandem mass spectroscopy in 701 girls and boys (14-18 years old, 54% blacks, 49% females). Cardiometabolic risk was indexed by adipokines, inflammatory markers, fasting glucose, homeostatic model assessment-insulin resistance (HOMA-IR), lipid profile, and blood pressures (BP).
RESULTS: Controlling for age, sex, race, sexual maturation, season, physical activity, and percent body fat, 25(OH)D concentrations were significantly correlated with adiponectin (r = 0.06, P = 0.05), leptin (r = -0.32, P < 0.01), fibrinogen (r = -0.05, P = 0.03), glucose (r = -0.16, P = 0.02), HOMA-IR (r = -0.17, P < 0.01), HDL cholesterol (r = 0.14, P = 0.02), systolic BP (r = -0.10, P = 0.02), and diastolic BP (r = -0.21, P < 0.01).
When 25(OH)D concentrations were stratified into increasing tertiles, there were significant linear upward trends for
- adiponectin (P = 0.01) and *
HDL cholesterol (P = 0.04),
but significant linear down trends for
- glucose (P < 0.01),
- HOMA-IR (P < 0.01), and
- systolic BP (P < 0.01),
after adjusting for the above covariates.
CONCLUSIONS: Circulating 25(OH)D concentrations are associated with various adverse cardiometabolic risk factors, independent of adiposity.
Clinical trials addressing the effects of vitamin D supplementation on cardiometabolic risk are warranted in adolescents irrespective of their geographical regions.
PMID: 22410810
- - - - - - - - - - - - - - - - - -
See also Vitamin D Life
- Overview Cardiovascular and vitamin D
- Vitamin D intervention reduced death due the heart failure by 32 percent – Feb 2012
- All items in Cardiovascular and Vitamin D 144 items as of Nov 2011
- 30 ng perhaps best for cardiovascular - graphs from many countries - 2011.pdf file
- Lack of vitamin D is a predictor of heart failure – Sept 2010
- More than 600 IU of vitamin D reduced male CVD risk by 16 percent – June 2011
- 24X less Calcification of Aorta for PAD with modest level of vitamin D – Aug 2011
- Metabolic Syndrome and vitamin D
- Metabolic Syndrome reduced 2X after one year of more sunlight – Nov 2011
- Sudden death 6X more likely with Metabolic Syndrome and low vitamin D – March 2012
- Global Metabolic risks, BMI, etc. - slides 2011.pdf file
- 70 % increased chance of Metabolic Syndrome if low on vitamin D – May 2011
- Metabolic Syndrome adults 4X more likely to have less than 20 ng of vitamin D – Jan 2011