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Obese children probably need more than 25,000 IU of vitamin D weekly – July 2014

Efficacy and Tolerability of a High Loading Dose (25,000 IU Weekly) Vitamin D3 Supplementation in Obese Children with Vitamin D Insufficiency/Deficiency

Hormone Research in Paediatrics Vol. 82, No. 2, 2014
Radhakishun N.N.E. · van Vliet M. · Poland D.C.W. · Weijer O. · Beijnen J.H. · Brandjes D.P.M. · Diamant M. · von Rosenstiel I.A.

Background: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with vitamin D insufficiency/deficiency. Methods: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (<50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D >50 nmol/l) was reached in >75% without side effects nor reaching toxic levels.

Results: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency (<50 nmol/l) to sufficiency (≥50 nmol/l). The majority of children that did not reach vitamin D sufficiency reported non-compliance. No side effects were reported, and the highest level reached was far below the threshold for toxicity.

Conclusion: A high loading dose vitamin D3 supplementation is effective and well-tolerated in our cohort of multiethnic obese children with vitamin D insufficiency/deficiency. © 2014 S. Karger AG, Basel

References

  1. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M: Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008;122:398-417.
  2. Rockell JE, Green TJ, Skeaff CM, Whiting SJ, Taylor RW, Williams SM, Parnell WR, Scragg R, Wilson N, Schaaf D, Fitzgerald ED, Wohlers MW: Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 years. J Nutr 2005;135:2602-2608.
  3. Alemzadeh R, Kichler J, Babar G, Calhoun M: Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008;57:183-191.
  4. The Health Council of the Netherlands (HCN): Evaluation of the dietary reference values for vitamin D. The Hague, HCN, 2012.
  5. Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL: Vitamin D status and response to vitamin D3 in obese vs. non-obese African-American children. Obesity 2008;16:90-95.
  6. Aquirre Castaneda R, Nader N, Weaver A, Singh R, Kumar S: Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents. Horm Res Paediatr 2012;78:226-231.
  7. Van Groningen L, Opdenoordt S, van Sorge A, Telting D, Giesen A, de Boer H: Cholecalciferol loading dose guideline for vitamin D-deficient adults. Eur J Endocrinol 2010;162:805-811.
  8. Vieth R: Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-856.
  9. Fredriks A, Van Buuren S, Wit J, Verloove-Vanhorick S: Body index measurements in 1996-1997 compared with 1980. Arch Dis Child 2000;82:107-112.
  10. Belenchia AM, Tosh AK, Hillman LS, Peterson CA: Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013;97:774-781.
  11. Jorens PG, Demey HE, Schepens PJ, Coucke V, Verpooten GA, Couttenye MM, Van Hoof V: Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose. J Toxicol Clin Toxicol 2004;42:163-169.
  12. Zosel A, Egelhoff E, Heard K: Severe lactic acidosis after an iatrogenic propylene glycol overdose. Pharmacotherapy 2010;30:219.

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Comments by Vitamin D Life

As with many other studies, this study would have better success if used any combientaion of the following

  1. Had extended the trial for more than 9 weeks
  2. Had used a loading dose
  3. Had used more than 25,000 IU

The lowest optimum level is 40 ng, Their 20 ng goal provides very few health benefits

See also Vitamin D Life

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Overview Obesity and Vitamin D contains the following summary

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