Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.
Front Immunol. 2019 Nov 22;10:2739. doi: 10.3389/fimmu.2019.02739
Cyprian F1, Lefkou E2, Varoudi K2, Girardi G1.
- Multiple Sclerosis – 3X higher incidence in women, previously 1X, wonder why
- Study on this page would probably point out that women today have fewer pregnancies
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Women resist infections better, but have more autoimmune diseases – Vitamin D- Dec 2016
Hashimoto's Thyroiditis
- Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
- Increased occurrence of Graves' and Hashimoto's diseases if poor Vitamin D genes – Nov 2014
- Hashimoto's Thyroiditis and Vitamin D - multiple studies
Autoimmune category starts with
164 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Muscular Dystrophy Lupus Psoriasis
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
Items in both categories Autoimmune and Pregnancy are listed here:
- Autoimmune disorders associated with low vitamin D during pregnancy – Nov 2019
- Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019
- Autoimmune Addison's Disease – increased risk if born in Dec or Jan – Nov 2016
- Increased cows milk allergy if Folic acid or Folate added to vitamin D during pregnancy – June 2016
- All pregnant women (in UK) should have free vitamin D – Gillie Aug 2015
- Vitamin D protects against many types of health problems – review May 2013
- High level of maternal vitamin D and infant food allergy – controversy
- Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012
- 2X more allergies if 11th womb week was in Spring – Vitamin D or pollen Oct 2010
Items in both categories Autoimmune and Women are listed here:
- Autoimmune disorders associated with low vitamin D during pregnancy – Nov 2019
- Hypothesis: Placentas cause more autoimmune diseases in females – July 2019
- Multiple Sclerosis – 3X higher incidence in women, previously 1X, wonder why
- Autoimmune diseases occur more often in women than men
- Endometriosis treated, and perhaps prevented, by vitamin D
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OAPS = Obstretic antiphospholipid syndrome - see description at the bottom of this page
In addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D on the production and action of several cytokines has been intensively investigated in recent years. In this connection, deficiency of vitamin D has been associated with several autoimmune diseases, including
(rheumatoid arthritis (RA),- systemic lupus erythematosus (SLE),
- antiphospholipid syndrome (APS),
- Hashimoto Thyroiditis (HT), and
- multiple sclerosis (MS).
In a successful pregnancy, the maternal immune response needs to adapt to accommodate the semiallogeneic fetus. Disturbances in maternal tolerance are implicated in infertility and pregnancy complications such as
- miscarriages (RM) and
- preeclampsia (PE).
It is well-known that a subset of T lymphocytes, regulatory T cells (Tregs) exhibit potent suppressive activity, and have a crucial role in curtailing the destructive response of the immune system during pregnancy, and preventing autoimmune diseases. Interestingly, vitamin D deficiency is common in pregnant women, despite the widespread use of prenatal vitamins, and adverse pregnancy outcomes such as RM, PE, intrauterine growth restriction have been linked to hypovitaminosis D during pregnancy. Research has shown that autoimmune diseases have a significant prevalence within the female population, and women with autoimmune disorders are at higher risk for adverse pregnancy outcomes. Provocatively, dysregulation of T cells plays a crucial role in the pathogenesis of autoimmunity, and adverse pregnancy outcomes where these pathologies are also associated with vitamin D deficiency. This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.
OAPS = Obstretic antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder. Signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures.1 APS occurs when your body's immune system makes antibodies that attack phospholipidsAutoimmune disorders associated with low vitamin D during pregnancy – Nov 2019Printer Friendly PDF this page! Follow this page for updates662 visitors, last modified 12 Dec, 2019, This page is in the following categories (# of items in each category)Pregnancy750 Autoimmune 164 Women 139 Attached files
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