Clinical Significance of Analysis of Vitamin D Status in Various Diseases
Nutrients 2020, 12(9), 2788; https://doi.org/10.3390/nu12092788
by Magdalena Kowalówka 1OrcID,Anna K. Główka 1OrcID,Marta Karaźniewicz-Łada 2,* and Grzegorz Kosewski 1
- 1 Department of Bromatology, Poznan University of Medical Sciences, 42 Marcelińska Street, 60-354 Poznań, Poland
- 2 Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland
Vitamin D Life suspects about half of the people with Vitamin D deficient diseases
have enough Vitamin D in their blood, but not in their cells
For many it is more important to increase vitamin D and D getting to cells than to get a Vitamin D test
Genes - some of which can be improved by supplements
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes etc.
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
35 items in CYP27B1 category 266 articles in the Genetics 384 articles in Vitamin D Receptor 141 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
Vitamin D blood test misses CYP27B1 and other genes
Cancers might alter CYP24A1 gene
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010
- 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012
- CYP24A1 gene in cancer cells may actually deactivate vitamin D – Oct 2012
141 items and the following introduction Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Vitamin D Binding Protein has a list of health problemsIncreased
RiskHealth Problem 11 X Preeclampsia 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2 X MS 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility Vitamin D Receptor
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators
- Vitamin D Receptor and Cancers
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- studies have found 50 Cancers associated with poor Vitamin D Receptor
- Some studies found that a Cancer has "learned" how to deactivate the Vitamin D receptor
- studies have found 50 Cancers associated with poor Vitamin D Receptor
- The activation of the Vitamin D receptor decreases with age 6 studies as of Sept 2020
Additional information on the Genes in Vitamin D Life
Gene # of pages Location CYP27A1 449 (Sept 2019) Liver CYP2R1 826 (Sept 2019) Liver & Tissue CYP27B1 1430 (Sept 2019) Kidney & Tissue CYP24A1 1360 (Sept 2020) excrete excess - Vitamins regulate some human genes – Feb 2020
- The genetics of vitamin D – Oct 2018
- Does survival of the less fit mean less health genes getting worse over generations
- More genes changed with higher doses of Vitamin D (suggest future gene studies) - RCT Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
Cofactors (in addition to Vitamin D Receptor supplements)
Vitamin D Cofactors in a nutshell table show the importance of eachSupplement # of
studiesIncrease D
to tissueOmega-3 330
Many benefits 30%? Magnesium 259
Many need Mg 30% Calcium 192
Reduce Vitamin K 127 Hard bones,
soft arteriesIron 53
Vitamin B12 42 Zinc 51 ?% Boron 29 +20% Iodine 24 Resveratrol 35 >100% if
poor VDRCurcumin 10 ? ?% if
poor VDR Download the PDF from Vitamin D Life
Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. Although numerous studies have reported on the analysis of vitamin D status in various groups of patients, the clinical significance of measurements of vitamin D forms and metabolites remains ambiguous. This article reviews the reports analyzing the status of vitamin D in various chronic states. Particular attention is given to factors affecting measurement of vitamin D forms and metabolites. Relevant papers published during recent years were identified by an extensive PubMed search using appropriate keywords. Measurement of vitamin D status proved to be a useful tool in diagnosis and progression of metabolic syndrome, neurological disorders and cancer. High performance liquid chromatography coupled with tandem mass spectrometry has become the preferred method for analyzing the various forms and metabolites of vitamin D in biological fluids. Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations.
Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020257 visitors, last modified 11 Sep, 2020, This page is in the following categories (# of items in each category)Vitamin D Receptor384 Vit D Binding Protein 141 CYP27B1 35 Attached files
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