Maternal blood pressure rise during pregnancy and offspring obesity risk at 4-7 years old: the Jiaxing Birth Cohort
Perhaps low vitamin D during pregnancy ==> Overweight child, hypertension not required
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Overweight children associated with low vitamin D during pregnancy – 2015, 2018 which has the following chart
- Preeclampsia (low vitamin D) doubles the risk of later cardiovascular problems – Sept 2019
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preeclampsia reduced 1.7 X by aspirin (but reduced 7 X by Vitamin D) – Feb 2018
- Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017
- Child 49 percent higher risk of being overweight if hypertension during pregnancy – Sept 2017
- Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- Preeclampsia is not reduced by vitamin D (if you ignore vitamin D level, dose size, frequency and duration) – July 2017
- Preeclampsia doubles the risk of mild cognitive impairment – July 2017
- No Hypertension during pregnancy if more than 60 ng of vitamin D – RCT
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Preeclampsia 4X less likely if vitamin D levels increased by 8 ng during pregnancy – March 2016
- Pre-eclampsia 2X more likely if low vitamin D, unless adjust for vitamin D factors (BMI, skin color) – Dec 2015
- Preeclampsia and eclampsia associated with lower vitamin D, etc. – Sept 2015
- Preeclampsia increased risk of Congenital Heart Defects by 60 percent (vitamin D not mentioned) Oct 2015
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- Burkas reduce vitamin D levels, which causes pregnancy problems – Oct 2015
- Preeclampsia – hypothesis as to why vitamin D helps – June 2015
- Preeclampsia inversely proportional to serum Magnesium – Oct 2014
- Hypertension in pregnancy (preeclampsia) more frequent in winter (low vitamin D) – Jan 2015
- Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
- Preeclampsia 40 percent less likely if mother had more than 20 ng of vitamin D – Jan 2014
- Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
- During pregnancy even 400 IU helps metabolic status – RCT July 2013
- 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013
- 7X increase in early severe preeclampsia associated with low vitamin D – Aug 2012
- Preeclampsia 3X more likely if low vitamin D at 25th week – April 2012
- Low vitamin D results in severe preeclampsia and low birth weight – Mar 2011
- Women with low vitamin D 4X more likely to have preeclampsia in pregnancy – Nov 2010
- Seasonal variation in pregnancy hypertension is correlated with sunlight intensity -June 2010 no abstract
Context: Maternal hypertensive disorders during pregnancy are suggested to have an impact on offspring obesity risk. However, little is known about the prospective association of rise in maternal blood pressure within normal range during pregnancy with offspring obesity risk. Objective: We aimed to clarify the associations of diastolic and systolic blood pressure during pregnancy among normotensive women with offspring obesity risk.
Design: Prospective cohort study.
Setting: Southeast China.
Participants: Up to 2013, 88,406 mother-child pairs with anthropometric measurements of the offspring between 4-7 years of age were included in the present analysis.
Main outcomes measured: Offspring overweight/obesity risk.
Results: Among normotensive women, second and third trimester diastolic and systolic blood pressure were positively associated with offspring overweight/obesity risk: odds ratios per 10 mmHg higher second and third trimester diastolic blood pressure were: 1.05 (95% confidence interval: 1.01, 1.09) and 1.05 (1.02, 1.10), respectively; and for systolic blood pressure: 1.08 (1.05, 1.11) and 1.06 (1.03, 1.09). Each 10 mmHg greater rise in blood pressure between first to third trimester was associated with higher risk of offspring overweight/obesity, with diastolic: 1.06 (1.01, 1.10) and systolic: 1.05 (1.02, 1.07). Among all women (combining normotensive and hypertensive women), maternal hypertension in the second and third trimester was associated with 49% and 14% higher risk of offspring overweight/obesity respectively.
Conclusions: These results suggest that rise in maternal blood pressure during pregnancy and pregnancy hypertension, independent of maternal body size prior to pregnancy, are risk factors for offspring childhood obesity. We studied the association between maternal pregnancy blood pressure and offspring obesity risk, and found that rise in pregnancy blood pressure was associated with a higher risk of offspring obesity